Virions of vesicular stomatitis virus are bullet-shaped because they contain two nested, left-handed protein helices.
"Vesicular stomatitis virus (VSV) is a bullet-shaped rhabdovirus and a model system of negative-strand RNA viruses. Through direct visualization by means of cryo–electron microscopy, we show that each virion contains two nested, left-handed helices: an outer helix of matrix protein M and an inner helix of nucleoprotein N and RNA. M has a hub domain with four contact sites that link to neighboring M and N subunits, providing rigidity by clamping adjacent turns of the nucleocapsid. Side-by-side interactions between neighboring N subunits are critical for the nucleocapsid to form a bullet shape, and structure-based mutagenesis results support this description. Together, our data suggest a mechanism of VSV assembly in which the nucleocapsid spirals from the tip to become the helical trunk, both subsequently framed and rigidified by the M layer." (Ge et al. 2010:689)
Learn more about this functional adaptation.
- Ge P; Tsao J; Schein S; Green TJ; Luo M; Zhou H. 2010. Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science. 327(5966): 689 - 693.
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