North American river otters are sometimes taken by bobcats, coyotes, birds of prey, alligators, and other large predators. They mainly escape predation through their agility in the water and on land, their vigilance, and their ability to fiercely defend themselves and their young.
- bobcats (Lynx_rufus)
- coyotes (Canis_latrans)
- birds of prey (Falconiformes)
- American alligators (Alligator_mississipiensis)
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