Another scientific name for False Rue Anemone is Isopyrum biternatum. This species blooms a little earlier than many other spring wildflowers in a woodlands, and it has attractive flowers and foliage. Two other members of the Buttercup family that occur in woodlands, Anemone quinequefolia (Wood Anemone) and Anemonella thalictroides (Rue Anemone), resemble False Rue Anemone. Wood Anemone has leaflets that are coarsely serrated along the margins and their lobes taper to sharp points; it also differs from False Rule Anemone by the whorl of leaves underneath the flowers. Rue Anemone also has whorled leaves underneath the flowers, otherwise its foliage is very similar to that of False Rue Anemone (which has alternate leaves along the stems). While Wood Anemone and Rue Anemone produce small clusters of beaked achenes (each containing a single seed within a hardened exterior), False Rue Anemone produces small clusters of beaked follicles that each contain 2 or more seeds. Sometimes the white flowers of Wood Anemone and Rue Anemone have more than 5 petal-like sepals, while the flowers of False Rue Anemone never have more than 5 petal-like sepals.
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