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Catharanthus roseus, commonly known as the Madagascar periwinkle, is a species of Catharanthus native and endemic to Madagascar. Other English names occasionally used include Cape periwinkle, rose periwinkle, rosy periwinkle, and "old-maid".
It is an evergreen subshrub or herbaceous plant growing to 1 m tall. The leaves are oval to oblong, 2.5–9 cm long and 1–3.5 cm broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm long; they are arranged in opposite pairs. The flowers are white to dark pink with a darker red centre, with a basal tube 2.5–3 cm long and a corolla 2–5 cm diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm long and 3 mm broad.
In the wild, it is an endangered plant; the main cause of decline is habitat destruction by slash and burn agriculture. It is also however widely cultivated and is naturalised in subtropical and tropical areas of the world.
Cultivation and uses 
The species has long been cultivated for herbal medicine and as an ornamental plant. In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, is used against several diseases. In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma. The substances vinblastine and vincristine extracted from the plant are used in the treatment of leukemia  and Hodgkin's lymphoma.
As an ornamental plant, it is appreciated for its hardiness in dry and nutritionally deficient conditions, popular in subtropical gardens where temperatures never fall below 5 °C to 7 °C, and as a warm-season bedding plant in temperate gardens. It is noted for its long flowering period, throughout the year in tropical conditions, and from spring to late autumn, in warm temperate climates. Full sun and well-drained soil are preferred. Numerous cultivars have been selected, for variation in flower colour (white, mauve, peach, scarlet and reddish-orange), and also for tolerance of cooler growing conditions in temperate regions. Notable cultivars include 'Albus' (white flowers), 'Grape Cooler' (rose-pink; cool-tolerant), the Ocellatus Group (various colours), and 'Peppermint Cooler' (white with a red centre; cool-tolerant).
C. roseus is used in plant pathology as an experimental host for phytoplasmas. This is because it is easy to infect with a large majority of phytoplasmas, and also often has very distinctive symptoms such as phyllody and significantly reduced leaf size.
Other names 
C. roseus is known as "noyontara" (Bengali: নয়নতারা) in Bengali, sadaphuli (Marathi: सदाफुली) in Marathi, boa-noite ("good night") and maria-sem-vergonha ("shameless maria", name shared with Impatiens and Thunbergia alata) in Portuguese (American), vinca-de-madagáscar, vinca-de-gato ("cats' vinca"), vinca-branca (white vinca), vinca or boa-noite in Portuguese (European), vinca del Cabo, vinca rosa ("pink vinca") or vinca rosada ("roseous vinca") in Spanish, and nityhakalyani in Tamil (Tamil: நித்யகல்யாணி பூ).
Grown in Malaysia
Flower plant raised in India Temples
Garden Plant in India
Common garden plant in India
- Flora of Madagascar: Catharanthus roseus
- Germplasm Resources Information Network: Catharanthus roseus
- Huxley, A., ed. (1992). New RHS Dictionary of Gardening. Macmillan ISBN 0-333-47494-5.
- Flora of China: Catharanthus roseus
- College of Micronesia: Catharanthus roseus
- Jepson Flora: Catharanthus roseus
- DrugDigest: Catharanthus roseus
- Karasov, C. (2001). "Who Reaps the Benefits of Biodiversity?". Environmental Health Perspectives (Environmental Health Perspectives, Vol. 109, No. 12) 109 (12): A582–A587. doi:10.2307/3454734. JSTOR 3454734. PMC 1240518. PMID 11748021.
- C. Marcone, A. Ragozzino, E. Seemuller (1997). "Dodder transmission of alder yellows phytoplasma to the experimental host Catharanthus roseus (periwinkle)". Forest Pathology 27 (6): 347–350. doi:10.1111/j.1439-0329.1997.tb01449.x.
- Chung-Jan Chang (August 12, 1997, Rochester, NY). "Pathogenicity of Aster Yellows Phytoplasma and Spiroplasma citri on Periwinkle". 89th Annual Meeting of the American Phytopathological Society.
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