Madagascar periwinkle is widely cultivated as an ornamental (see "How to Grow"). Large quantities of material are required for production of the anticancer alkaloids vincristine and vinblastine or derivatives thereof, which to date cannot be manufactured synthetically. A substantial body of research exists regarding means of enhancing indole alkaloid production in cell and tissue cultures.
Moreno, P. R. H., R. van der Heijden and R. Verpoorte. 1995. Cell and tissue cultures of Catharanthus roseus: A literature survey. Plant Cell Tiss. Org. Cult. 42: 1-25.
Snoeijer, W. 1996. Catharanthus roseus, the Madagascar Periwinkle, a review of its cultivars. Wageningen Agricultural University Papers 96(3): 47-120.
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