EOL recently launched the Global Genome Initiative Knowledge Portal, essential infrastructure for the Smithsonian-led initiative to archive genomics-quality tissue across the tree of life. The GGI Knowledge Portal reports for six major databases how much information exists for every family (e.g. specimens, literature, GenBank records, rich EOL pages) and highlights where data are apparently absent. A composite GGI score enables quick comparisons of the relative state of knowledge for each group. A collaboration with ITIS enabled this ground-breaking comprehensive gap analysis.