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Fusobacterium nucleatum

Fusobacterium nucleatum is a heterogenous species of Gram negative, strictly anaerobic, non-motile, non spore forming bacteria, which is currently divided into 5 recognized subspecies: fusiforme, nucleatum, vincentii, animalis and polymorphum.  Cell morphology is highly variable between strains, although all cells are fusiform, with cell length ranging from ~5-50uM depending on the strain.  F.nucleatum is indigenous to the human oral and gastrointestinal tracts, and is an important component of oral plaque, serving as a bridge species in the oral biofilm.  The species is increasingly recognized as an opportunistic, invasive pathogen, and is a causative agent of Lemierre's Disease, and as well is associated with a range of pathologies such as periodontitis, abscesses, pre-term labour and stillbirth, appendicitis, Crohn's disease and colorectal cancer.   The genome size is approximately 2.5Mbp and is extremely AT rich (G+C ~28mol%).  


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