Fgene-09-00595-g001

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Description: English: Schematic representation of flavivirus vRNA. (A) vRNA is composed of a 5′UTR, one single open reading frame and a 3′UTR. The position of the sequences encoding for the viral proteins within the polyprotein is indicated. The bottom part of the figure shows in details the secondary structures of 5′UTR, capsid-coding region and 3′UTR. The different regions engaged in local pseudoknots and long-range RNA–RNA interactions are indicated and described in detail in the text. (B) Predicted structure of vRNA in its circularized conformation. The coding sequence (except 5′ capsid coding region) is depicted with a dashed line. Date: 4 December 2018. Source: Mazeaud C, Freppel W and Chatel-Chaix L (2018) The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis. Front. Genet. 9:595. doi: 10.3389/fgene.2018.00595 https://www.frontiersin.org/articles/10.3389/fgene.2018.00595/full. Author: Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix.